Lenvatinib with pembrolizumab for the treatment of squamous cell carcinoma of the head and neck


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Lenvatinib in combination with pembrolizumab is being developed as a first-line therapy for adults with programmed death-ligand 1 (PD-L1) expressing recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). HNSCC is a cancer of the mouth, nose or throat that develops in the squamous cells found in the outer layer of skin and the mucous membranes that line body cavities

Therapeutic Areas: Head and Neck Cancer
Year: 2022

Lenvatinib in combination with pembrolizumab is being developed as a first-line therapy for adults
with programmed death-ligand 1 (PD-L1) expressing recurrent or metastatic head and neck
squamous cell carcinoma (HNSCC). HNSCC is a cancer of the mouth, nose or throat that develops
in the squamous cells found in the outer layer of skin and the mucous membranes that line body
cavities. About a half of the patients with HNSCC have it return after treatment (recurrent) or it
spread to other parts of the body (metastatic). Recurrent/metastatic HNSCC is a difficult disease
to treat, with poor prognosis and survival rates.