Romosozumab arose from a genetic discovery that revealed the body’s own natural ability to increase bone strength. It is a treatment which aims to block the activity of the protein sclerostin. This diminishes bone breakdown and removal and stimulates bone formation, thereby increasing bone strength. The effectiveness and safety of romosozumab for the treatment of osteoporosis in men has been studied in a phase III clinical trial. The study showed that romosozumab given by injection monthly for a 12 month period significantly increased the formation of new bones, reducing the risk of a fracture. Romosozumab was also found to be safe with no significant adverse effects.