Venetoclax is a drug that attaches to a protein in the body called Bcl-2. This protein presents in high amounts in CLL cancer cells, where it helps the cancer cells survive for longer in the body and makes them resistant to cancer medicines. Venetoclax causes the death of cancer cells and thereby slows the progression of the disease. In combination with obinutuzumab the body’s immune system gets strengthened. If licenced, venetoclax with obinutuzumab will offer an additional treatment option for patients with previously untreated CLL.
Venetoclax in Combination with Obinutuzumab for the Treatment of Previously Untreated Chronic Lymphocytic Leukaemia – First Line
Interventions: Obinutuzumab (Gazyvaro; RO5072759; GA101; Afutuzumab) , Venetoclax (Venclyxto; ABT-199; Venclexta; GDC-0199)
Indications: Chronic lymphocytic leukaemia (CLL)
Therapeutic Areas: Haematological Cancer and Lymphomas