logo
Menu

This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders.

Innovation Observatory > Reports > Drugs > Afamitresgene autoleucel for advanced synovial sarcoma or myxoid/round cell liposarcoma

< Back

Afamitresgene autoleucel for advanced synovial sarcoma or myxoid/round cell liposarcoma

Drugs

Cancer and Palliative Care

July 2021


Afamitresgene autoleucel is in clinical development for the treatment of advanced synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) in patients who have previously had chemotherapy. Both synovial sarcoma and MRCLS are two different types of soft tissue sarcomas (STS), a rare form of cancer that develops in the tissues that connect, support and surround other body structures and organs. Advanced synovial sarcoma or MRCLS means that the cancer has spread to other parts of the body. Currently there are limited therapies available for these patients, so there is a need to develop additional treatment options.
Afamitresgene autoleucel is a medicinal product designed using a patient’s own T-cells (a type of white blood cell). The T-cell is genetically modified so that it produces a protein that attaches to a protein known as MAGE-A4. MAGE-A4 is found on cancerous cells in synovial sarcoma and MRCLS. When afamitresgene autoleucel is administered as a single intravenous infusion it recognises and attaches to MAGE-A4 cancerous cells via the human leukocyte antigen (HLA)-A*02 protein which is found at the surface of the cancerous cells, and kills them. If licenced, afamitresgene autoleucel would offer an additional treatment option for advanced synovial sarcoma or MRCLS, and would be the first approved T-cell therapy for these patients.

Innovation Observatory Voice 0

Leave a Reply

Your email address will not be published. Required fields are marked *

Post Comment

Download Full Article



 

Connect to the Innovation Observatory

Twitter

Load More Related Posts

Get Alerts