Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

| 46 Results

Clear All Filters

Title	Intervention	Indication	Therapeutic Area	Year	Actions
Tezacaftor/ivacaftor (fixed-dose combination) for cystic fibrosis heterozygous for F508del mutation and one residual mutation in patients aged 6 to 11 years	Ivacaftor (Kalydeco; VX-770) , Symkevi (fixed dose combination: Tezacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2019	View \| Download
Tezacaftor and ivacaftor for cystic fibrosis homozygous or heterozygous for F508del mutation in patients aged 12 years and older who discontinued treatment with Orkambi	Ivacaftor (Kalydeco; VX-770) , Symkevi (fixed dose combination: Tezacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2019	View \| Download
Sotatercept for treating pulmonary arterial hypertension	Sotatercep (ACE-011)	Pulmonary arterial hypertension (PAH)	Cardiovascular System , Respiratory System	2022	View \| Download
Nintedanib for treating interstitial lung disease in children aged 6 to 17 years old	Nintedanib (Vargatef; Ofev; nintedanib esilate)	Interstitial lung disease (ILD)	Dermatology , Respiratory System	2022	View \| Download
Nintedanib for Systemic Sclerosis Associated Interstitial Lung Disease	Nintedanib (Vargatef; Ofev; nintedanib esilate)	Interstitial lung disease (ILD)	Dermatology , Respiratory System	2018	View \| Download
Nintedanib for progressive fibrosing interstitial lung disease	Nintedanib (Vargatef; Ofev; nintedanib esilate)	Progressive fibrosing interstitial lung disease (PF-ILD)	Respiratory System	2019	View \| Download
Mepolizumab add-on therapy for chronic obstructive pulmonary disease with eosinophil-associated exacerbations	Mepolizumab (Nucala; SB-240563; SB-240563 autoinjector)	Chronic obstructive pulmonary disease (COPD)	Respiratory System	2024	View \| Download
Macitentan-tadalafil for treating pulmonary arterial hypertension	Macitentan-tadalafil	Pulmonary arterial hypertension (PAH)	Cardiovascular System , Respiratory System	2022	View \| Download
Macitentan for treating pulmonary arterial hypertension in children	Macitentan	Pulmonary arterial hypertension (PAH)	Cardiovascular System , Respiratory System	2022	View \| Download
Lumacaftor and Ivacaftor (Orkambi) for Cystic Fibrosis Homozygous for the F508del Mutation in Patients Aged 6‐11 Years	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download