Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Vemurafenib (Zelboraf) for BRAF V600 mutation positive melanoma; completely resected but at high risk of recurrence	Vemurafenib (Zelboraf; PLX4032; R7204; RO5185426; PLX-4032; RG7204)	Melanoma	Skin Cancer	2017	View \| Download
Talimogene laherparepvec in addition to pembrolizumab for metastatic melanoma	Pembrolizumab (Keytruda; MK-3475) , Talimogene laherparepvec (Imlygic; T-Vec)	Melanoma	Skin Cancer	2020	View \| Download
Spartalizumab in addition to dabrafenib and trametinib for unresectable or metastatic BRAF V600 mutant melanoma – first‐line	Dabrafenib (Tafinlar; GSK2118436; dabrafenib mesilate) , Spartalizumab (PDR001) , Trametinib (Mekinist; TMT212; GSK-1120212B; GSK1120212; JTP-74057; trametinib dimethyl sulfoxide)	Melanoma	Skin Cancer	2019	View \| Download
Seviprotimut-L for Malignant Melanoma after Surgery	Seviprotimut-L (POL-103A)	Melanoma	Skin Cancer	2018	View \| Download
Retifanlimab for advanced/metastatic merkel cell carcinoma	Retifanlimab (INCMGA00012; MGA-012)	Merkel cell carcinoma (MCC)	Skin Cancer	2021	View \| Download
Relatlimab in combination with nivolumab for advanced melanoma – second line	Nivolumab (Opdivo; BMS-936558; ONO-4538) , Relatlimab (BMS-986016; Anti-LAG-3)	Melanoma	Skin Cancer	2019	View \| Download
PV-10 for Locally Advanced Cutaneous Melanoma	PV-10 (rose bengal sodium)	Melanoma	Skin Cancer	2018	View \| Download
Pembrolizumab in combination with lenvatinib for advanced melanoma – first line	Lenvatinib (Kisplyx; E7080; lenvatinib mesilate) , Pembrolizumab (Keytruda; MK-3475)	Melanoma	Skin Cancer	2021	View \| Download
Pembrolizumab in Combination with Epacadostat for Unresectable or Metastatic Melanoma	Epacadostat (INCB024360) , Pembrolizumab (Keytruda; MK-3475)	Melanoma	Skin Cancer	2018	View \| Download
Pembrolizumab as adjuvant therapy for resected high-risk stage II melanoma	Pembrolizumab (Keytruda; MK-3475)	Melanoma	Skin Cancer	2020	View \| Download