Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Elexacaftor/tezacaftor/ivacaftor and ivacaftor for treating cystic fibrosis without an F508del mutation and with an ELX/TEZ/IVA-responsive mutation in the CFTR gene in patients aged 6 years and older	Ivacaftor (Kalydeco; VX-770) , Kaftrio (fixed dose combination: Elexacaftor; Tezacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2023	View \| Download
Elexacaftor/tezacaftor/ivacaftor (fixed-dose combination) for cystic fibrosis homozygous for F508del mutation in patients aged 6 to 11 years old	Elexacaftor (VX-445) , Ivacaftor (Kalydeco; VX-770) , Symkevi (fixed dose combination: Tezacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2019	View \| Download
Elexacaftor/tezacaftor/ivacaftor (fixed-dose combination) for cystic fibrosis heterozygous for F508del mutation in patients aged 12 years old and older	Elexacaftor (VX-445) , Ivacaftor (Kalydeco; VX-770) , Tezacaftor (VX-661)	Cystic fibrosis	Genetic Disorders , Respiratory System	2020	View \| Download
Elexacaftor/tezacaftor/ivacaftor (fixed-dose combination) for cystic fibrosis heterozygous for F508del mutation and one minimal function mutation in patients aged 6 to 11 years	Elexacaftor (VX-445) , Ivacaftor (Kalydeco; VX-770) , Symkevi (fixed dose combination: Tezacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2019	View \| Download
Dupilumab in addition to controller medications for children aged 6 to 11 years with asthma	controller medications , Dupilumab (Dupixent; REGN-668; SAR-231893; REGN668; SAR231893)	Asthma	Respiratory System	2021	View \| Download
Dupilumab for treating Chronic obstructive pulmonary disease (COPD)	Dupilumab (Dupixent; REGN-668; SAR-231893; REGN668; SAR231893)	Chronic obstructive pulmonary disease (COPD)	Respiratory System	2022	View \| Download
Depemokimab as adjunctive therapy for severe asthma with an eosinophilic phenotype in patients aged 12 years and older	Depemokimab	Asthma	Respiratory System	2024	View \| Download
Dapsone for treating COVID-19	Dapsone (PULM-001;Pulmonem)	COVID-19	Respiratory System	2023	View \| Download
Cysteamine bitartrate for cystic fibrosis exacerbations	Cysteamine bitartrate (Procysbi; RP103; Lynovex; NM001; Cystadrops; Mercaptamine)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Ceftobiprole medocaril for treating hospital-acquired pneumonia or community-acquired pneumonia requiring hospitalisation in children	Ceftobiprole medocaril	Community-acquired pneumonia , Hospital-acquired pneumonia	Infectious Disease , Respiratory System	2022	View \| Download