Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Leuprorelin acetate in addition to tamoxifen or an aromatase inhibitor for ER-positive early stage breast cancer in premenopausal women - adjuvant	Leuprorelin acetate (Prostap DCS; Prostap Depot) , Tamoxifen	Breast cancer	Breast Cancer	2018	View \| Download
Lisocabtagene Maraleucel (Liso-Cel) for Relapsed/Refractory Diffuse Large B-cell Lymphoma	Lisocabtagene maraleucel (Liso-cel; JCAR017)	Diffuse large B-cell lymphoma (DLBCL)	Haematological Cancer and Lymphomas	2018	View \| Download
Lumacaftor and Ivacaftor (Orkambi) for Cystic Fibrosis Homozygous for the F508del CFTR mutation in patients aged 2-5 years old	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Lumacaftor and Ivacaftor (Orkambi) for Cystic Fibrosis Homozygous for the F508del Mutation in Patients Aged 6‐11 Years	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Luspatercept for adult patients with beta-thalassemia who require red blood cell transfusions	Luspatercept (ACE-536; Reblozyl)	Beta thalassemia	Genetic Disorders , Haematology	2018	View \| Download
Luspatercept for myelodysplastic syndromes (MDS) associated anaemia	Luspatercept (ACE-536; Reblozyl)	Anaemia due to myelodysplastic syndromes (MDS)	Haematological Cancer and Lymphomas , Haematology	2018	View \| Download
Mexiletine for the Symptomatic Treatment of Myotonic Disorders – First Line	Mexiletine hydrochloride (Namuscla)	Myotonia	Musculoskeletal System , Neurology	2018	View \| Download
Mirvetuximab Soravtansine for Platinum-resistant Ovarian Cancer	Mirvetuximab soravtansine (IMGN853)	Epithelial ovarian cancer , Fallopian tube cancer , primary peritoneal cancer	Female Reproductive Cancer	2018	View \| Download
Naloxone Auto-injector (Evzio) for Opioid Substance Use Disorder	Naloxone hydrochloride (Evzio; Narcan; OPNT001; Nalscue; Nalcol; E-0316)	Opioid overdose	Toxicology	2018	View \| Download
Nefecon (targeted-release budesonide formulation) for IgA Nephropathy (Berger's disease)	Budesonide targeted-release (Nefecon; PL-56)	IgA nephropathy	Immunology , Nephrology	2018	View \| Download