Human C1-esterase inhibitor (subcutaneous injection) for preventing hereditary angioedema

Human C1-esterase inhibitor (C1-INH) subcutaneous (SC) is licenced for the prevention of hereditary angioedema (HAE). HAE is a rare genetic disorder of blood vessels characterised by recurrent episodes of severe swelling (angioedema) below the skin which often affect the face, throat, stomach, hands or feet, causing discomfort and pain. People with HAE have reduced levels of a protein called C1-esterase inhibitor in their blood. C1-esterase inhibitor is a protein required to control the proteins in the blood that fight infections. HAE may be life threatening when the swelling occurs in the throat as it can obstruct the airways and impede breathing.