Linzagolix for treating endometriosis-associated pain

Linzagolix is in clinical development for the treatment of endometriosis-associated pain. Endometriosis is when the endometrium (the tissue that lines the inside of the uterus or womb) starts to grow outside of the uterus, including in the ovaries and fallopian tubes. Each month, this misplaced tissue first builds up then breaks down, but since it cannot leave the body it remains in place and causes irritation and inflammation. Symptoms can include: excessively painful menstrual cramps that may be felt in the abdomen or lower back, abnormal or heavy menstrual flow, infertility and discomfort when going to the toilet. Current treatments are limited to painkillers, neuromodulators and neuropathic treatments. Hormonal treatments can also be recommended, but cannot improve fertility.