Pylera with omeprazole for treating helicobacter pylori associated ulcers

Pylera in combination with omeprazole is currently in development for the treatment of adults who test positive for Helicobacter pylori (H. pylori) with upper gastrointestinal symptoms. H. pylori infection occurs when H. pylori bacteria infect the stomach, which typically happens during childhood. The bacteria are usually passed from person to person through direct contact with saliva, vomit, or stool. It can also spread through contaminated food or water. H. pylori infection is a common cause of stomach ulcers. H. pylori treatment usually involves a triple-therapy regimen comprising a proton pump inhibitor (PPI) – a type of drug that reduces acid production in the stomach and two antibiotics. Antibiotics are key components of many first-line PPI-based triple therapies, but resistance to them is constantly rising, meaning they are no longer effective at clearing the bacteria, which leads to treatment failures.