Telisotuzumab vedotin for previously treated c-MET overexpressing EGFR wild-type non-squamous non-small cell lung cancer

Telisotuzumab vedotin is in development for the treatment of c-Met+ non-small cell lung cancer. Non-small cell lung cancer is the most common form of lung cancer. A c-Met is a protein in humans that is encoded by the MET gene that leads to growth in cells. Smoking is the cause of most lung cancers and the biggest risk factor. Other risk factors include second-hand smoke, exposure to workplace carcinogens, radiation exposure, environmental pollution, and family history of lung cancer. Current standard of care treatment can help to control the cancer for some time and reduce symptoms, however, sometimes non-small cell lung cancer can continue to grow despite chemotherapy and immunotherapy.