Tezepelumab for treating severe chronic rhinosinusitis with nasal polyps

Tezepelumab is in clinical development for the treatment of severe chronic rhinosinusitis with nasal polyps. Chronic rhinosinusitis is a condition in which the lining of the sinuses (air-filled spaces behind the nose, eyes, and cheeks) becomes inflamed for more than 12 weeks. People with the condition may have nasal polyps which are growths inside the nasal passages and sinuses. This is called chronic rhinosinusitis with nasal polyps (CRSwNP), for which the cause is not completely understood, however it is more common in people with other conditions including asthma. Symptoms include nasal blockage, loss of smell, continuous runny nose, and lower airway problems. Oral or intranasal steroid treatments are usually the first approach but if these are ineffective, then sinus surgery may be needed. However, these options are not a permanent solution because polyps tend to recur and are associated with risks.