Daratumumab in addition to pomalidomide and dexamethasone is in clinical development for relapsed or refractory multiple myeloma (MM). MM is a rare, incurable cancer of the plasma cells in the bone marrow where large amounts of abnormal plasma cells are produced and interfere with the production of red and white blood cells and platelets. People […]
Daratumumab injected under the skin (subcutaneous formulation) is in development for the treatment multiple myeloma (MM) as an alternative to currently approved daratumumab intravenous formulation. MM is a rare, incurable cancer of the plasma cells in the bone marrow where large amounts of abnormal plasma cells are produced and interfere with the production of platelets, […]
Daratumumab is a new drug for the treatment of multiple myeloma (Kahler disease). The drug acts by targeting some specific cells that destroys the cancer cells and also improve the body’s natural immune response. The safety and efficacy of daratumumab is currently being evaluated for use in combination with lenalidomide and dexamethasone in patients with […]
Daridorexant is a medicinal product in clinical development for the treatment of adults with insomnia. Insomnia means regularly having problems sleeping, which results in impaired daytime functioning. Insomnia can be categorised according to its duration, into short-term insomnia (lasting less than 4 weeks) and long-term (or persistent) insomnia (lasting 4 weeks or longer). Daridorexant is […]
Currently, there are no approved therapies for the treatment of NASH, but doctors recommend dietary changes and exercise to prevent or slow disease progression. Volixibat is a new experimental once-daily oral tablet that may improve NASH by targeting and blocking a protein (apical sodium-dependent bile acid transporter) found in the liver. This is thought to […]
Cutaneous melanoma is a type of skin cancer. It is the most aggressive and life-threatening form of skin cancer, and can appear anywhere on the body. Locally advanced cutaneous melanoma means the cancer has spread from the skin to the nearby tissue and lymph nodes. The symptoms of advanced melanoma may not appear until years […]
Cutaneous T‐cell lymphoma (CTCL) is a rare type of non‐Hodgkin lymphoma that affects the skin. It iscaused by white cells, called lymphocytes, growing in an uncontrolled way. CTCL usually develops veryslowly and at an early stage topical treatments of the localised accumulation of the cancer are usuallyused. At a later, more advanced stage, systemic treatments […]
Cystic fibrosis is an inherited disease that has severe effects on the lungs and the digestive system. It affects the cells that produce mucus and digestive juices. In cystic fibrosis, the secretions become thick and cause blockage within the tissues and organs (mostly within the lungs). Build-up of thick and sticky secretions in the lungs […]
Dabigatran etexilate is an oral drug that acts by preventing clots from forming and blocking blood vessels. It is already available for the treatment and prevention of stroke and other types of blood clots affecting blood vessels and organs in the body. By preventing clots from forming, it can prevent future embolic strokes. This could […]
Dapagliflozin as a tablet is in clinical development for the treatment of heart failure (HF) with preserved ejection fraction. HF is a complex clinical syndrome of symptoms and signs that suggest the efficiency of the heart as a pump is impaired. Symptoms include breathlessness and fatigue, and signs of the condition include swollen ankles and […]
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