Burosumab is in clinical development for the treatment of adults with X-linked hypophosphataemia (XLH), and is currently licenced in children. XLH is an inherited disorder characterized by low levels of phosphate in the blood. Phosphate levels are low because phosphate is abnormally processed in the kidneys due to high levels of a protein called FGF23, […]
Burosumab is in clinical development for the treatment of adults with tumour-induced osteomalacia (TIO). TIO is a rare disease where an overproduction of FGF23 leads to renal phosphate wasting and low levels of phosphate and vitamin D in the body. This causes weakening (or softening) of bones. Main symptoms include bone pain, muscle weakness/fatigue and […]
Brentuximab is a type of monoclonal antibody (MA). MAs target particular proteins on the cancer cells surface. Brentuximab targets a protein called CD 30, it sticks to the CD30 protein and delivers a drug to the cell. The drug then kills the cell. Early trials suggest that patients may find treatment with brentuximab easier to […]
Brentuximab vedotin in addition to cyclophosphamide, doxorubicin, prednisolone (CHP) as intravenous infusion is in development for the treatment of CD30+ mature T-cell lymphoma also known as peripheral T cell lymphoma (PTCL), a subtype of non-Hodgkins lymphoma. PTCL is a group of aggressive and fast growing lymphomas that develop from mature white blood cells called T-cells […]
Brexanolone as an injection for intravenous infusion is in clinical development for women with moderate and severe postpartum depression (PPD). PPD is a mood disorder that can affect women after childbirth. Women with PPD experience feelings of extreme sadness, anxiety, and exhaustion that may make it difficult for them to complete daily care activities for […]
Brigatinib is a medicinal product that is being developed for the treatment of patients with locally advanced or metastatic ALK-positive non-small cell lung cancer (NSCLC) whose disease have progressed following treatment with alectinib or ceritinib. NSCLC is the most common type of lung cancer although a small proportion of NSCLC patients have a rearrangement in […]
Brolucizumab is in clinical development for the treatment of visual impairment due to diabetic macular oedema (DMO). DMO is a condition affecting the retina, the nerve layer at the back of the eye. The central part of the retina known as the macula, is responsible for fine detail vision, both for near (reading) and for […]
Budesonide 9mg gastro-resistant granules are in clinical development for the induction of remission in patients with lymphocytic colitis. Lymphocytic colitis is an inflammatory bowel disease that causes bouts of severe diarrhoea. Certain medications, viruses and bacteria can trigger lymphocytic colitis, however the cause of the disease is not known; it is thought that genetic and […]
Budesonide is in clinical development for ulcerative proctitis. Ulcerative proctitis is a mild form of ulcerative colitis, a chronic inflammatory bowel disease (IBD) consisting of small ulcers that develop on the colon’s lining, which can cause rectal bleeding and recurring diarrhoea. About a quarter of the patients that are diagnosed with ulcerative colitis may also […]
Breast cancer, a cancer that develops from the tissues of the breast, is the most common cancer in the UK. There are many types of breast cancer and they are often grouped based on the presence or absence of some specific types of proteins (‘receptors’) in the cells of the patient. The most common type […]
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