JNJ-68284528 is in clinical development for the treatment of relapsed and/or refractory multiple myeloma (MM). MM is a rare, incurable cancer of the plasma cells in the bone marrow. Abnormal plasma cells interfere with the production of red and white blood cells as well as platelets, causing symptoms such as bone pain and fragility, weakness, […]
Istradefylline has been developed as an add-on treatment for adult patients receiving levodopa-based regimens for Parkinson’s disease (PD), who are experiencing end of dose fluctuations. PD is neurodegenerative condition resulting from the loss of the dopamine-containing cells of the substantia nigra. There is no cure for PD and symptoms are usually seen in motor-development and […]
Irritable bowel syndrome with constipation (IBS-C) is a common condition that affects the digestive system (the gut). Symptoms may include stomach cramps, bloating and constipation. The exact cause is unknown, and IBS-C is often a lifelong condition. While there is no cure, dietary changes and the use of medication can often help control symptoms. IBS-C […]
Ipatasertib in addition to paclitaxel is in clinical development for the treatment of adults with locally advanced or metastatic triple-negative breast cancer (TNBC) with PIK3CA/AKT1/PTEN-altered tumour. This type of breast cancer is caused by a combination of genetic abnormalities and loss of some genes in the body. TNBC is an uncommon type of breast cancer […]
Isatuximab in addition to bortezomib, lenalidomide and dexamethasone is currently in clinical development as a first-line therapy option for patients with newly diagnosed multiple myeloma (MM) who are not eligible for autologous stem cell transplant (ASCT). MM may or may not be symptomatic in the early stages, but eventually leads to a range of problems. […]
Isatuximab in addition to carfilzomib and dexamethasone is in clinical development for patients with multiple myeloma (MM) who are refractory or have relapsed to prior treatments. MM is a rare, incurable cancer of the plasma cells in the bone marrow where large amounts of abnormal plasma cells are produced and interfere with the production of […]
Inclisiran is in clinical development for treatment of hypercholesterolaemia in patients at high risk of cardiovascular disease in addition to, or after use of, oral anti‐lipidaemics including statins. Abnormal levels of lipids in the blood characterises dyslipidaemia. High levels of cholesterol in the blood (hypercholesterolemia) may be caused by inherited genetic defects as seen in […]
Influenza or ‘flu’ is a common virus infection which causes high temperature, body aches, tiredness, cough, sore throat, headache, diarrhoea and nausea. Flu is usually spread by coughs and sneezes and occurs in annual flu seasons (commonly October to May). There are two main types of virus which cause flu: Influenza A and Influenza B. […]
Inolimomab is being developed for the treatment of grade II to IV steroid-refractory acute Graft versus Host Disease (aGvHD) in adult patients after allogeneic haematopoietic stem cell transplantation (aHSCT). GvHD is characterised as a frequent complication of bone marrow transplantation and involves a reaction between the donor cells and the recipient's native tissues, leading to […]
Ipatasertib in addition to abiraterone and prednisone is in clinical development for the first line treatment of metastatic castrate resistant prostate cancer (mCRPC). Prostate cancer is a cancer of the prostate gland and mCRPC is when the cancer has spread to parts of the body other than the prostate, and it is able to grow […]
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