Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Kaftrio (Elexacaftor/tezacaftor/ivacaftor) and ivacaftor for treating cystic fibrosis in children (2 to 5 years) with at least one F508del mutation in the CFTR gene	Kaftrio (fixed dose combination: Elexacaftor; Tezacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2022	View \| Download
Lenabasum for Diffuse Cutaneous Systemic Sclerosis	Lenabasum (JBT-101)	Systemic sclerosis	Dermatology , Respiratory System	2018	View \| Download
Levosimendan for respiratory function in amyotrophic lateral sclerosis	Levosimendan (OR1259; Simdax; Leximda)	Respiratory dysfunction	Neurology , Respiratory System	2020	View \| Download
Liposomal cyclosporine A for treating bronchiolitis obliterans syndrome after lung transplant	Liposomal Cyclosporin A (L-CsA)	Bronchiolitis obliterans	Respiratory System	2023	View \| Download
Lumacafor/ivacaftor (fixed-dose combination) for cystic fibrosis homozygous for F508del mutation in patients aged 12 to 23 months	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2019	View \| Download
Lumacaftor and Ivacaftor (Orkambi) for Cystic Fibrosis Homozygous for the F508del CFTR mutation in patients aged 2-5 years old	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Lumacaftor and Ivacaftor (Orkambi) for Cystic Fibrosis Homozygous for the F508del Mutation in Patients Aged 6‐11 Years	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Macitentan for treating pulmonary arterial hypertension in children	Macitentan	Pulmonary arterial hypertension (PAH)	Cardiovascular System , Respiratory System	2022	View \| Download
Macitentan-tadalafil for treating pulmonary arterial hypertension	Macitentan-tadalafil	Pulmonary arterial hypertension (PAH)	Cardiovascular System , Respiratory System	2022	View \| Download
Mepolizumab add-on therapy for chronic obstructive pulmonary disease with eosinophil-associated exacerbations	Mepolizumab (Nucala; SB-240563; SB-240563 autoinjector)	Chronic obstructive pulmonary disease (COPD)	Respiratory System	2024	View \| Download