Topical rapamycin cream for treating facial angiofibroma

Topical rapamycin cream is in clinical development for the treatment of facial angiofibroma (FA) associated with tuberous sclerosis complex (TSC). TSC is a rare genetic disorder that affects genes that regulate cell growth. TSC is often associated with FA, which are pinkish or reddish bumps usually located on the cheeks, nose and chin. Although FAs are benign, they can bleed, block nasal passages, cause facial disfigurement, and impair patient functions such as vision and breathing. Typical treatments include laser surgery (using heat to destroy abnormal cells), cryotherapy (using extreme cold to freeze abnormal cells) and dermabrasion (mechanically wearing away abnormal cells). However, these treatments can be painful, may lead to scarring and do not prevent recurrence. Therefore, other less invasive treatment options are required.