Melanoma is the most common skin cancer in the UK and is characterised by changes to mole size or shape. It is when melanocytes (cells that give skin its tan or brown colour) grow uncontrollably. Stage II melanoma is where the cancer has spread locally, as opposed to other areas of the body, and can […]
Mepolizumab is a medicinal product currently in development as an add-on for the treatment of hypereosinophilic syndrome (HES). HES is a rare group of inflammatory disorders characterised by an overproduction of eosinophils (a type of disease-fighting white blood cell). When eosinophils infiltrate certain tissues, they can cause inflammation and organ damage which, over time, can […]
Melphalan flufenamide in combination with dexamethasone is currently in clinical development for the treatment of adult patients with relapsed or refractory multiple myeloma (MM). MM is a rare, incurable cancer of the plasma cells in the bone marrow where large amounts of abnormal plasma cells are produced and interfere with the production of red and […]
Mirikizumab is in clinical development for the treatment of adult patients with moderately to severely active ulcerative colitis (UC). UC is a long-term condition where the colon and rectum (parts of the bowel), become inflamed. Small ulcers can develop on the colon’s lining, which can cause rectal bleeding and recurring diarrhoea. The symptoms of ulcerative […]
Migalastat is in clinical development for the treatment of Fabry disease for children aged 12 to 15 years old. Fabry disease is a rare genetic disorder caused by a defective gene (the GLA gene) in the body. In most cases, the defect in the gene causes a deficient quantity of the enzyme alpha-galactosidase A. This […]
Mepolizumab is in development for the treatment of chronic rhinosinusitis with polyposis (polyps) (CRSwNP). Nasal polyps are characterised by oedema (swelling) and accumulation of a type of white blood cell called eosinophils. Nasal polyps cause symptoms such as nasal blockage, loss of smell and rhinorrhoea (frequent runny nose). The cause of CRSwNP is not completely […]
Melanoma is a cancer of the skin and can occur anywhere on the skin. Unusual moles, exposure to sunlight and sunburn can affect the risk of having melanoma. When the cancer has spread into the bones, the lymph nodes or glands nearby it is said to be at the advanced (metastatic) stage. Often at this […]
Mavorixafor (X4P-001) is in clinical development for the treatment of WHIM syndrome in patients aged 12 years and above. WHIM stands for warts (skin growths), hypogammaglobulinemia (low level of antibodies), infections and myelokathexis (a condition where immune cells are trapped in the bone marrow preventing them from fighting infections). Patients with WHIM syndrome have mutations […]
Mavacamten is currently being developed for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (oHCM) in adults. Hypertrophic cardiomyopathy (HCM) is a genetic condition whereby areas of heart muscle become thickened and stiff. Blood decreases in the left ventricular volume and narrowing of the left ventricular outflow tract (LVOT) is classified as obstructive HCM (oHCM). HCM […]
Maribavir is being developed for the treatment of cytomegalovirus (CMV) infections and the first indication expected for maribavir is for patients that are clinically refractory and/or genetically resistant to ganciclovir (GCV), valganciclovir (VGCV), cidofovir (CDV) and foscarnet (FOS). CMV is a common virus that usually only causes mild infection. In people with weakened immunity, such […]
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