Search All Tech Briefings


Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available.  Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

| 15 Results

Title
Intervention Indication Therapeutic Area Year Actions
Atezolizumab (Tecentriq) and Cobimetinib (Cotellic) for advanced/metastatic colorectal cancer - third line Atezolizumab (Tecentriq; MPDL3280A) , Cobimetinib (Cotellic; GDC-0973; cobimetinib hemifumarate) Colorectal cancer Gastrointestinal Cancer , Oncology 2017 View  |  Download
Belzutifan for von Hippel-Lindau disease-associated clear cell renal cell carcinoma – first line Belzutifan (PT2977; MK-6482) Renal cell carcinoma (RCC) Genetic Disorders , Oncology , Renal Cancer 2021 View  |  Download
Encorafenib in combination with binimetinib and cetuximab for BRAF V600E mutant metastatic colorectal cancer Binimetinib (MEK162; MEK-162; ARRY-162) , Cetuximab (Erbitux; STI-001) , Encorafenib (LGX818) Colorectal cancer Gastrointestinal Cancer , Oncology 2019 View  |  Download
Entrectinib for the Treatment of NTRK-fusion Positive Solid Tumours in Adult and Paediatric Patients Entrectinib (RXDX-101) Solid tumours Haematological Cancer and Lymphomas , Oncology 2018 View  |  Download
Erdafitinib for treating advanced solid tumours with an FGFR mutation in people aged 6 years and older Erdafitinib (JNJ-42756493; BALVERSA) Solid tumours Haematological Cancer and Lymphomas , Oncology 2021 View  |  Download
Glucarpidase for methotrexate toxicity Glucarpidase (Voraxaze) Methotrexate toxicity during cancer therapy Oncology , Toxicology 2022 View  |  Download
IMCgp100 for the Treatment of Advanced or Metastatic Uveal Melanoma IMCgp100 (Tebentafusp) Uveal melanoma Oncology 2017 View  |  Download
Larotrectinib (LOXO-101) for advanced solid cancers [with an NTRK1, NTRK2, or NTRK3 gene fusion] Larotrectinib (LOXO-101; Viktravi; larotrectinib sulfate) Solid tumours Haematological Cancer and Lymphomas , Oncology 2017 View  |  Download
Nivolumab in combination with ipilimumab for cisplatin-ineligible patients with untreated, unresectable or metastatic urothelial cancer– first line Ipilimumab (Yervoy; BMS 734016; MDX 101) , Nivolumab (Opdivo; BMS-936558; ONO-4538) Bladder cancer Oncology , Urological Cancer 2021 View  |  Download
Pembrolizumab for Stage IV Colorectal Carcinoma – first line Pembrolizumab (Keytruda; MK-3475) Colorectal cancer Gastrointestinal Cancer , Oncology 2018 View  |  Download
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