Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Larotrectinib (LOXO-101) for advanced solid cancers [with an NTRK1, NTRK2, or NTRK3 gene fusion]	Larotrectinib (LOXO-101; Viktravi; larotrectinib sulfate)	Solid tumours	Haematological Cancer and Lymphomas , Oncology	2017	View \| Download
IMCgp100 for the Treatment of Advanced or Metastatic Uveal Melanoma	IMCgp100 (Tebentafusp)	Uveal melanoma	Oncology	2017	View \| Download
Glucarpidase for methotrexate toxicity	Glucarpidase (Voraxaze)	Methotrexate toxicity during cancer therapy	Oncology , Toxicology	2022	View \| Download
Futibatinib for treating cholangiocarcinoma with FGFR2 gene rearrangements	Futibatinib	Cholangiocarcinoma	Haematological Cancer and Lymphomas , Oncology	2023	View \| Download
Fruquintinib for treating refractory metastatic colorectal cancer	Fruquintinib (Elunate; TAK113; HMPL013)	Colorectal cancer	Gastrointestinal Cancer , Oncology	2023	View \| Download
Favezelimab-pembrolizumab for treating metastatic PD-L1 positive colorectal cancer	Favezelimab-pembrolizumab	Colorectal cancer	Gastrointestinal Cancer , Oncology	2023	View \| Download
Erdafitinib for treating advanced solid tumours with an FGFR mutation in people aged 6 years and older	Erdafitinib (JNJ-42756493; BALVERSA)	Solid tumours	Haematological Cancer and Lymphomas , Oncology	2021	View \| Download
Entrectinib for the Treatment of NTRK-fusion Positive Solid Tumours in Adult and Paediatric Patients	Entrectinib (RXDX-101)	Solid tumours	Haematological Cancer and Lymphomas , Oncology	2018	View \| Download
Encorafenib in combination with binimetinib and cetuximab for BRAF V600E mutant metastatic colorectal cancer	Binimetinib (MEK162; MEK-162; ARRY-162) , Cetuximab (Erbitux; STI-001) , Encorafenib (LGX818)	Colorectal cancer	Gastrointestinal Cancer , Oncology	2019	View \| Download
Cabozantinib with atezolizumab for treating metastatic castration-resistant prostate cancer after one novel hormonal therapy	Atezolizumab (Tecentriq; MPDL3280A) , Cabozantinib (XL-184; Cabometyx; Cometriq; XL 184)	Prostate cancer	Haematological Cancer and Lymphomas , Oncology	2023	View \| Download