Inclisiran is in clinical development for treatment of hypercholesterolaemia in patients at high risk of cardiovascular disease in addition to, or after use of, oral anti‐lipidaemics including statins. Abnormal levels of lipids in the blood characterises dyslipidaemia. High levels of cholesterol in the blood (hypercholesterolemia) may be caused by inherited genetic defects as seen in […]
Imlifidase is in clinical development for enabling kidney transplantation in highly sensitised patients with chronic kidney disease (CKD). CKD is a long-term irreversible condition where the kidneys do not work as well as they should. Kidney transplantation is considered to be treatment of choice for patients with end stage kidney disease. Many patients on the […]
Influenza or ‘flu’ is a common virus infection which causes high temperature, body aches, tiredness, cough, sore throat, headache, diarrhoea and nausea. Flu is usually spread by coughs and sneezes and occurs in annual flu seasons (commonly October to May). There are two main types of virus which cause flu: Influenza A and Influenza B. […]
Inolimomab is being developed for the treatment of grade II to IV steroid-refractory acute Graft versus Host Disease (aGvHD) in adult patients after allogeneic haematopoietic stem cell transplantation (aHSCT). GvHD is characterised as a frequent complication of bone marrow transplantation and involves a reaction between the donor cells and the recipient's native tissues, leading to […]
Ibrutinib in addition to rituximab is being developed for young and fit untreated patients with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). CLL is a type of cancer in which too many white blood cells are produced. As these cells develop abnormally, they are unable to function, fight infection and reduce the production […]
IgA nephropathy (IgAN) also known as Berger’s disease is one of the most common kidney diseases, aside from those caused by high blood pressure or diabetes. It is an autoimmune (where the immune cells attack the body) disease affecting the kidneys. IgA antibodies are molecules made by immune cells which help stop intruders from attacking […]
Idasanutlin in addition to cytarabine is in development for the treatment of relapse or refractory Acute Myeloid Leukaemia (AML). AML is a type of cancer that causes the bone marrow (the soft inner part of the bones where new blood cells are made) to produce excess immature white blood cells. The term acute means that […]
Ibrutinib is in clinical development for chronic graft versus host disease (cGvHD). After a donor stem cell transplant, the donor’s stem cells (the graft) may sometimes react against the host’s own cells. This is called Graft versus Host Disease (GvHD). cGvHD may happen more than three months after transplant. The symptoms depend on which parts […]
Ibrutinib is a drug which blocks signals in cancer cells which helps the cancer cell survive and grow resulting in the cells death and preventing the cancer from growing. Early clinical trials of ibrutinib in follicular lymphoma (FL) patients suggest it may reduce symptoms and ongoing clinical trials will determine if ibrutinib will extend life […]
Ibrutinib in combination with venetoclax is being developed for elderly and at risk patients with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). CLL and SLL are types of cancer in which too many white blood cells are produced, in SLL cells build up in the lymph nodes, in CLL the cancer cells can […]
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