Fevipiprant is in clinical development for the treatment of patients aged 12 years and older with uncontrolled asthma who remain symptomatic despite treatment with inhaled corticosteroids (ICS) with or without at least one additional controller. Whilst there is no cure for asthma, most patients are able to control their symptoms by taking daily preventative medication […]
Familial primary hypoalphalipoproteinemia (FPHA), also known as familial high-density lipoprotein (HDL) deficiencies, are rare genetic disorders. HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body. […]
Faricimab is in clinical development for adults with diabetic macular oedema (DMO). DMO is a type of eye disease where blood vessels leak fluid into the retina. Vision loss occurs when the fluid reaches the macula (the centre of the retina that provides sharp vision) and builds up, causing swelling. Over time, DMO can cause […]
Fenfluramine hydrochloride is in clinical development as a treatment for paediatric and adult patients with Lennox-Gastaut syndrome. Lennox-Gastaut syndrome is a rare and severe form of epilepsy that is most commonly found in children. It is characterised by slow mental development and various types of seizures that are difficult to treat. As patients enter into […]
Evinacumab is in clinical development for the treatment of homozygous familial hypercholesterolemia (HoFH). Familial hypercholestrolaemia (FH) is an inherited condition where a person’s cholesterol levels are higher than normal from birth as the liver is unable to break down or remove excess cholesterol. Specifically, FH patients have severe elevations in low density lipoprotein cholesterol (LDL-C) […]
Familial adenomatous polyposis (FAP) is rare condition that can often run in families, but it can also develop in people who do not have a family history of the condition. FAP causes hundreds or thousands of small growths called polyps to develop in the large bowel. These polyps are not cancerous, but if they are […]
Fedovapagon is in clinical development as an oral treatment for nocturia in men with benign prostate enlargement. Nocturia is a common symptom in men who have enlarged prostates. Nocturia is generally defined as excessive or disruptive (either due to the volume of urine or frequency of trips to the toilet) night-time urination which disrupts sleep […]
Faricimab is in clinical development for the treatment of neovascular (wet) age-related macular degeneration (nAMD). AMD is an eye condition that blurs the centre of a person’s vision and is the most common cause of sight loss in the developed world. There are two types of AMD – wet and dry. Wet AMD develops when […]
Etranacogene dezaparvovec is in development for the treatment of moderately severe or severe haemophilia B in adult males. Haemophilia B is a hereditary bleeding disorder that results in the blood taking longer to clot than normal. The disorder is caused by having a faulty version of the F9 gene. The F9 gene provides instructions for […]
Etrolizumab is in clinical development for the treatment of adult patients with moderately to severely active ulcerative colitis. Ulcerative colitis is a long-term condition where the colon and rectum (parts of the bowel), become inflamed. Small ulcers can develop on the colon’s lining, which can cause rectal bleeding and recurring diarrhoea. The symptoms of ulcerative […]
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