Garetosmab is in clinical development for the prevention of abnormal bone formation, outside of the normal skeleton (heterotopic ossification), and soft-tissue flare-ups in patients with fibrodysplasia ossificans progressiva (FOP). FOP is a very rare disease caused by a mutation in the gene ACVR1. The mutation results in the formation of unwanted bone in muscles, tendons, […]
GISTs with D842V mutation in PDGFRA are usually resistant to the currently available targeted cancer drugs. Crenolanib is a medicine that specifically blocks the PDGFRA pathway involved in the production of blood vessels that supply the cancer cells, thereby preventing the cancer cells from growing and multiplying. It is being developed for the treatment of […]
Gefapixant is in clinical development for the treatment of refractory or unexplained chronic cough. Cough is a normal reflex response to airway irritation, triggered by stimulation of airway cough receptors, which protect against choking and enhances airway clearance. Chronic refractory cough (defined as a cough lasting more than 8 weeks in adults) collectively refers to […]
Giant cell arteritis (GCA) is an autoimmune condition that causes the inflammation of large and medium sized blood vessels. An alternative name for this condition is “Temporal Arteritis” as the blood vessels in the temple area of the head (sides of the forehead) are commonly affected. The “giant” cells are abnormal large cells that develop […]
Gastric cancer is cancer that starts anywhere inside the stomach or the stomach wall. Advanced gastric cancer can be locally advanced (has spread into the tissues around the stomach) or metastatic (has spread to at least one other part of the body such as the liver). Most gastric cancer cases are diagnosed at a late […]
Filgotinib is in clinical development for the treatment of patients with moderately to severely active ulcerative colitis. Ulcerative colitis is a type of inflammatory bowel disease that causes inflammation and ulcers in the bowel and rectum which can cause diarrhoea, abdominal pain and faecal urgency or incontinence. The symptoms of ulcerative colitis often follow a […]
Galcanezumab is being developed as one of a class of specific anti-migraine preventative drugs. By stopping a very specific protein in the brain and nervous system, galcanezumab reduces migraine attacks. Additionally as it is given once-a-month as treatment, it avoids the need to take numerous pills per day. If marketed, galcanezumab may be more preferable […]
Fostemsavir is in clinical development for human immunodeficiency virus-1 (HIV-1) infection in heavily treatment-experienced adults. HIV is a virus that damages the cells in the immune system and weakens the body’s ability to fight everyday infections and diseases. HIV infection is incurable but there are effective treatments that enable most infected people to live a […]
Filgotinib is in development for the treatment of adults with moderate to severe active rheumatoid arthritis (RA) as front-line therapy or for those which previous treatment with a disease-modifying anti-rheumatic drug (DMARD) has not worked or are unable to take it. RA is a long-term, autoimmune disease that causes pain, swelling and stiffness in the […]
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