Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Dapagliflozin for chronic heart failure with reduced ejection fraction	Dapagliflozin (Forxiga; BMS512148; Farxiga; dapagliflozin propanediol monohydrate)	Heart failure (HF)	Cardiovascular System	2019	View \| Download
Danicopan with eculizumab or ravulizumab for treating paroxysmal nocturnal haemoglobinuria	Danicopan (ACH-0144471; ACH-4471; ALXN2040) , Ravulizumab (ALXN1210; Ultomiris)	Paroxysmal nocturnal haemoglobinuria (PNH)	Haematology	2022	View \| Download
Dabrafenib with Trametinib with adjuvant therapy for treating advanced BRAF V600 mutation-positive melanoma in adolescents	Dabrafenib (Tafinlar; GSK2118436; dabrafenib mesilate) , Trametinib (Mekinist; TMT212; GSK-1120212B; GSK1120212; JTP-74057; trametinib dimethyl sulfoxide)	Melanoma	Skin Cancer	2023	View \| Download
Dabrafenib with trametinib for treating paediatric BRAF V600 mutated high-grade or low-grade glioma	Dabrafenib (Tafinlar; GSK2118436; dabrafenib mesilate) , Trametinib (Mekinist; TMT212; GSK-1120212B; GSK1120212; JTP-74057; trametinib dimethyl sulfoxide)	Glioma	Neurological Cancer	2022	View \| Download
Dabrafenib with trametinib for treating metastatic or unresectable BRAF V600 mutation-positive melanoma in adolescents	Dabrafenib (Tafinlar; GSK2118436; dabrafenib mesilate) , Trametinib (Mekinist; TMT212; GSK-1120212B; GSK1120212; JTP-74057; trametinib dimethyl sulfoxide)	Melanoma	Skin Cancer	2023	View \| Download
Dabigatran Etexilate (Pradaxa) for Secondary Stroke Prevention in Patients with Embolic Stroke of Undetermined Source – First Line	Dabigatran etexilate (Pradaxa)	Ischaemic stroke	Cardiovascular System	2017	View \| Download
Cysteamine bitartrate for cystic fibrosis exacerbations	Cysteamine bitartrate (Procysbi; RP103; Lynovex; NM001; Cystadrops; Mercaptamine)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Cysteamine bitartrate (Procysbi) delayed release for Huntington’s Disease	Cysteamine bitartrate (Procysbi; RP103; Lynovex; NM001; Cystadrops; Mercaptamine)	Huntington's disease	Genetic Disorders , Neurology	2017	View \| Download
CTX001 for transfusion-dependent beta-thalassaemia	CTX001	Beta thalassemia	Genetic Disorders , Haematology	2021	View \| Download
CTX001 for severe sickle cell disease	CTX001	Leukocyte adhesion deficiency , Sickle cell disease (SCD)	Haematology , Immunology	2021	View \| Download