Liposomal bupivacaine is in late-stage clinical development for the treatment of postoperative pain in adults. Post-operative pain is a common occurrence for those patients who have surgery. Controlling post-operative pain is important for ensuring a good patient experience, optimising post-operative outcomes and enhancing recovering, and the prevention of chronic postsurgical pain in the longer term. […]
Liposomal cytarabine-daunorubicin is currently being developed for paediatric patients with relapsed or refractory acute myeloid leukaemia (AML). AML is an aggressive type of blood cancer that starts from certain types of white blood cells in the bone marrow. AML results in abnormal white blood cells being produced too quickly, resulting in them accumulating in the […]
Levodopa, carbidopa monohydrate and entacapone intestinal gel (LECIG, TRICEL, Lecigon) is in development to treat severe motor fluctuations in advanced Parkinson’s disease (PD). PD is a progressive neurological disease caused by a loss of nerve cells in a particular part of the brain that results in decreased levels of the chemical messenger dopamine. This results […]
Leuprorelin acetate in addition to tamoxifen or an aromatase inhibitor is in clinical development as an adjuvant treatment of ER-positive early stage breast cancer in premenopausal women at higher risk of disease recurrence (young age, high grade tumour, lymph node involvement). Breast cancer is the most common female cancer in the UK. In early stage […]
Leuprorelin acetate is being developed as an adjuvant treatment given by subcutaneous injection for pre and perimenopausal women with advanced breast cancer suitable for hormonal manipulation. Breast cancer is the most common female cancer in the UK. Breast cancers that are stimulated to grow by the hormones oestrogen or progesterone are known as hormone receptor-positive […]
Lenvatinib in combination with pembrolizumab is in clinical development for the treatment of hepatocellular carcinoma (HCC), which is cancer that originally develops in the liver and accounts for nine in ten primary liver cancer cases. Advanced or unresectable HCC occurs when the cancer has spread to lymph nodes or to other organs and cannot be […]
Lenvatinib in combination with pembrolizumab is in clinical development for the treatment of advanced or recurrent endometrial cancer. Endometrial cancer is the most common form of womb cancer and originates from the lining of the womb (endometrium). The most common symptoms of this cancer are post-menopausal or irregular vaginal bleeding. Standard of care for patients […]
Leronablim is in clinical development to treat experienced adult HIV-1 patients infected with C-C chemokine receptor type 5 (CCR5)-tropic virus. Antiretroviral medicines are used to treat HIV. However, poor adherence and the subsequent development of drug resistance is one reason why HIV treatment can fail and therefore requires more treatment options. Leronlimab is an antibody […]
Lenvatinib in combination with pembrolizumab is in clinical development for the treatment of advanced endometrial cancer. Endometrial cancer is the most common form of womb cancer and originates from the lining of the womb (endometrium). The most common symptoms of this cancer are post-menopausal or irregular vaginal bleeding. For patients with advanced endometrial cancers who […]
Lenvatinib in addition to pembrolizumab is in clinical development for the treatment of adults with treatment-naive, metastatic, stage IV, non-small cell lung cancer (NSCLC), with Programmed cell Death-Ligand 1 (PD-L1) expression in at least 1% of tumour cells. NSCLC makes up the majority of lung cancers in the UK. Stage IV (advanced/metastatic) NSCLC is when […]
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