Lenalidomide is a drug, administered as a tablet, which affects the activity of the immune system and may impact the growth and spread of cancer cells. An ongoing phase III clinical trial explores whether offering it together with rituximab (an antibody) could be a viable therapy option for patients who have not had any prior […]
Lenvatinib in combination with pembrolizumab is in clinical development for the treatment of advanced endometrial cancer. Endometrial cancer is the most common form of womb cancer and originates from the lining of the womb (endometrium). The most common symptoms of this cancer are post-menopausal or irregular vaginal bleeding. For patients with advanced endometrial cancers who […]
KTE-C19 is a therapy where some of the patient's blood cells are removed, engineered to contain a compound which targets and kills the lymphoma cells, and re-injected into the patient. It requires blood to be taken from the patient and then a single intravenous administration of treated cells, which may stay active in the body […]
Lacosamide is a medicinal product that is being developed for the treatment of Primary Generalised Tonic-Clonic Seizures (PGTCS). Epilepsy is a neurological disorder that is characterised by an imbalance in the excitation and inhibition of the brain and this imbalance causes a phenomenon known as a seizure. Seizures are brief increases in electrical activity within […]
Lasmiditan is a medicinal product currently in clinical development for the acute treatment of migraine. A migraine is usually a moderate or severe headache felt as a throbbing pain on one side of the head. Many people also have symptoms such as nausea, vomiting and increased sensitivity to light or sound. Migraines may be with […]
Lebrikizumab is being developed for patients (aged 12 years to adult) with moderate to severe atopic dermatitis (AD). AD is a chronic inflammatory skin disease that affects both children and adults and is characterised by redness, itchiness, and scaling of the skin. Some people only have small patches of dry skin, but others may experience […]
Lenalidomide in addition to a chemotherapy combination known as R-CHOP is in clinical development for newly diagnosed, previously untreated adult patients with diffuse large B-cell lymphoma (DLBCL) of the subtype known as activated B-cells (ABC) type. DLBCL is a cancer affecting a type of white blood cells called lymphocytes or B-cells. It is the most […]
LAM-561 in addition to radiation therapy and temozolomide is in development as a treatment option for newly diagnosed glioblastoma patients. Glioblastoma is a fastgrowing brain tumour that develops from glial cells in the brain, is an aggressive brain cancer that typically results in death within months following diagnosis if not treated. Brain cancers are the […]
JNJ-68284528 is in clinical development for the treatment of relapsed and/or refractory multiple myeloma (MM). MM is a rare, incurable cancer of the plasma cells in the bone marrow. Abnormal plasma cells interfere with the production of red and white blood cells as well as platelets, causing symptoms such as bone pain and fragility, weakness, […]
Ixekizumab as subcutaneous injection is in clinical development for people with radiographic and non-radiographic axial spondyloarthritis who have not responded favourably to previous non-steroidal anti-inflammatory drug (NSAID) therapy. Axial spondyloarthritis is a chronic form of arthritis that causes significant inflammatory low back and/or buttock pain that persists more than three months. The condition affects the […]
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