Lisocabtagene maraleucel is in clinical development for the treatment of adult patients with high-risk, relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (NHL). In NHL, the affected lymphocytes start to multiply abnormally and begin to collect in certain parts of the body such as the lymph nodes. Aggressive or high-grade lymphomas tend to grow very quickly. […]
LN-145 is in development for the treatment of recurrent, metastatic or persistent cervical cancer. Recurrent cancer is when the cancer returns months or years after the original treatment; persistent cancer is when the tumour does not respond to treatment or a second tumour develops despite the completion of treatment. Metastatic cancer is when the tumour […]
Lisocabtagene maraleucel is in clinical development as a treatment for adult patients with aggressive B-cell non-Hodgkin lymphoma (NHL) who are relapsed or refractory to a single line of immunochemotherapy (and whom are ineligible for stem cell transplantation). In NHL, the affected lymphocytes start to multiply in an abnormal way and begin to collect in certain […]
Loncastuximab tesirine is currently in clinical development for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL). DLBCL is a type of blood cancer that develops when white blood cells, called lymphocytes, grow out of control. The affected lymphocytes lose their infection fighting ability making the body more susceptible ot infection. Relapsed cancer […]
Lonafarnib is in clinical development for the treatment of Hutchinson-Gilford Progeria syndrome (HGPS) and other progeroid laminopathies (PL). Progeroid laminopathies are characterised by the premature appearance of certain signs of physiological ageing in a subset of tissues, and the most prevalent of these rare diseases is HGPS. HGPS is caused by genetic abnormalities in a […]
Liposomal cytarabine-daunorubicin is currently being developed for paediatric patients with relapsed or refractory acute myeloid leukaemia (AML). AML is an aggressive type of blood cancer that starts from certain types of white blood cells in the bone marrow. AML results in abnormal white blood cells being produced too quickly, resulting in them accumulating in the […]
Liposomal bupivacaine is in late-stage clinical development for the treatment of postoperative pain in adults. Post-operative pain is a common occurrence for those patients who have surgery. Controlling post-operative pain is important for ensuring a good patient experience, optimising post-operative outcomes and enhancing recovering, and the prevention of chronic postsurgical pain in the longer term. […]
linatumomab is a type of drug called a monoclonal antibody. Monoclonal antibodies work by seeking out cancer cells by looking for particular proteins on the cells’ surface. Blinatumomab is a new drug that is already used to treat ALL in adults and is currently being studied to see how well it works and whether it […]
Ligelizumab is in clinical development for the treatment of chronic spontaneous urticaria (CSU) in adult and adolescent patients. CSU is a skin condition characterised by raised and itchy rash (wheals) and/or angioedema that has lasted for more than six weeks, in the absence of an identified external cause (spontaneous) and in some cases up to […]
Lifileucel is being developed for the treatment of patients with unresectable or metastatic melanoma who have previously been treated with at least one systemic therapy. Melanoma is characterised by the uncontrolled growth of melanocytes, which are cells that protect against ultraviolet radiation through the production of the dark pigment melanin. Advanced or metastatic (stage IV) […]
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